Mathematical Models of the Pharmacokinetic Behavior Acetaminophen in Rats

In pharmacokinetics, mathematical modeling is usually preformed using only a measured concentration time profile of a drug administered in plasma and/or in blood. In contrast, if a modeling method based on the theory of dynamic systems is used in pharmacokinetics, then the mathematical modeling is performed using both: a mathematically described drug administration and a mathematically described body response to an administered drug. The main advantage of a modeling method based on the theory of dynamic systems is that, under the condition that the pharmacokinetic behavior of an administered drug is linear then an identical model structure can be used for e.g. an intravenous administration of a drug, an oral administration of a drug, an intramuscular administration of a drug and so on. An explanatory picture and some of full texts journal articles, written in a tutorial way, are available completely free of costs at: http://www.uef.sav. sk/durisova.htm and http://www.uef.sav.sk/advanced.htm.